Ozonated Glycerine for Advanced Therapeutic Care

Ozonated glycerine is created by bubbling medical-grade ozone gas (O₃) through pure USP-grade vegetable glycerine. The ozone reacts with glycerine's hydroxyl groups to form stabilized byproducts including peroxides, aldehydes, ketones, and organic acids. These compounds are held in a water-soluble glycerine matrix that slowly releases therapeutic agents over weeks. OG has an estimated 90-day half-life at room temperature.

Ozonated glycerine outperforms ozone water in stability (90 days vs. 40 minutes) and matches ozone oil's longevity while being water-soluble. Unlike ozone oil which stays on the skin surface, OG penetrates cell membranes and enters mitochondria. It is odorless, non-staining, and suitable for mucosal, oral, and nebulized applications where ozone oil cannot be used.

Ozonated glycerine is generally considered safe for topical and mucosal applications. Japanese studies (Wang et al., 2011) confirmed its safety for skin, eyes, and oral mucosa. It is non-toxic, free of antibiotics and steroids, and well-tolerated even on sensitive skin. However, it is not FDA-approved for any medical condition and should be used under qualified medical supervision. Always consult a healthcare professional before use.

Professor Yoshiharu Okamoto of Tottori University has conducted pioneering research suggesting OG's potential in cancer treatment. The proposed mechanism involves cancer cells absorbing OG molecules during glycolysis (mistaking them for glucose metabolites), followed by slow release of ROS and peroxides that exploit cancer cells' disrupted antioxidant defenses. Clinical studies show ozone selectively inhibits growth of breast, lung, and uterine cancer cells while normal cells remain unaffected. This research is experimental and not FDA-approved.

Ozonated glycerine has diverse applications including: wound healing (diabetic ulcers, burns, surgical wounds), skin conditions (eczema, psoriasis, age spots, anti-aging), oral health (dental infections, gingivitis), respiratory support (sinusitis, lung infections, nebulized therapy), systemic health (Long COVID, Lyme disease, autoimmune conditions), and integrative oncology support. It can be used topically, orally, as a nasal spray, nebulized, or via clinical administration protocols.

Ozonated glycerine was first created in 1889 by French chemist Charles Marchand, a graduate of the École Centrale des Arts et Manufactures de Paris. Marchand discovered that passing ozone gas through pure glycerine created a stable therapeutic compound, which he named "Glycozone." He published his work in the book "The Therapeutical Applications of Peroxide of Hydrogen (medicinal), Glycozone and Hydrozone" (1904).

Marchand believed the active ingredient was hydrogen peroxide (H₂O₂) formed by the reaction H₂O + O₃ → H₂O₂ + O₂. He also created "Hydrozone" (his medicinal H₂O₂ preparation) and warned that simply mixing H₂O₂ with glycerine does NOT produce Glycozone — the ozone-glycerine reaction creates something entirely unique. Glycozone faded with the rise of antibiotics but has experienced a major resurgence since 2004, with Japanese studies proving its bactericidal effects, SARS-CoV-2 inactivation (2021), and emerging cancer research (2024).